Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma
نویسندگان
چکیده
منابع مشابه
Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.
Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs). To define the landscape of somatic mutations in pediatric osteosarcoma, we performed whole-genome sequencing of DNA from 20 osteosarcoma tumor samples and matched normal tissue in a discovery cohort, as well as 14 samples in a validation coho...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2014
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2014.03.003